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a: Control group: normal red pulp (
) and white pulp (
); b: Nicotine-treated group (1 mg/kg bw/day): degeneration of red pulp (
) and white pulp (
); c: CMC-EDBE-FA treated group (1 mg/kg bw/day): red pulp (
) and white pulp (
); d: CMC-EDBE-FA supplemented group (1 mg/kg bw/day): regenerating of red pulp (
).
