Table 2. Inflammatory markers, lipid peroxidation, protein oxidation, glutathione cycle and anti-oxidant enzyme status in vancomycin treated VSSA and VRSA infected group for 5 days.
| Parameter | Control | VSSA infection control | VSSA infection +100 mg/kg bw NV | VSSA infrction +500 mg/kg bw NV | VRSA infection control | VRSA infection +100 mg/kg bw NV | VRSA infection +500 mg/kg bw NV | |
| Viable bacteria count in blood (CFU/mL) | 0 | 209 735.00±1 807.13* | 66 367.00±2 337.12# | 69 367.00±1 697.37# | 292 189.00±2 258.18* | 143 116.00±1645.74# | 71 810.00±1 938.04# | |
| Serum | NO release (µM/ mg protein) | 23.37±0.38 | 39.02±0.39* | 26.11±0.38# | 28.01±0.40# | 45.78±0.40* | 30.12±0.38# | 25.99±0.40# |
| CRP (µg/dL) | 5.04±0.20 | 9.99±0.20* | 5.37±0.19# | 6.34±0.18# | 11.31±0.21* | 8.13±0.17# | 6.52±0.17# | |
| MPO (µM/mg protein) | 0.93±0.03 | 1.42±0.40* | 0.98±0.04# | 1.10±0.03# | 2.14±0.04* | 1.51±0.03# | 1.21±0.03# | |
| TNF-α (pg/mL) | 90.57±1.93 | 198.32± 2.11* | 118.74±1.87# | 125.74±1.79# | 233.78±4.71* | 164.74±3.67# | 117.96±2.79# | |
| IL-10 (pg/mL) | 225.12±4.76 | 133.12±2.91* | 201.23±3.79# | 178.17±3.17# | 97.34±2.61* | 175.37±3.59# | 192.17±3.63# | |
| Lymphocyte | NO generation (µM/mg protein) | 15.69±0.21 | 30.96±0.28* | 19.98±0.24# | 22.01±0.28# | 34.37±0.28* | 23.38±0.27# | 20.12±0.28# |
| MDA (µmol/mg protein) | 57.27±1.29 | 121.10±3.28* | 68.02±1.29# | 73.23±1.31# | 147.29±3.11* | 87.89±2.09# | 77.89±2.07# | |
| PC (µmol/mg protein) | 20.12±0.38 | 45.35±0.50* | 27.34±0.37# | 29.32±0.38# | 53.27±0.42* | 32.43±0.35# | 25.32±0.35# | |
| GSH (µg/mg protein) | 13.00±0.32 | 6.54±0.22* | 11.37±0.30# | 10.99±0.30# | 5.96±0.27* | 8.99±0.24# | 11.36±0.30# | |
| GSSG (µg/mg protein) | 35.78±1.34 | 71.38±2.02* | 46.33±1.81# | 51.37±1.88# | 75.29±2.03* | 55.12±1.90# | 45.16±1.78# | |
| SOD (Unit/mg protein) | 66.64±2.23 | 24.38±1.02* | 57.21±1.87# | 53.32±1.88# | 21.78±1.12* | 44.98±1.78# | 51.98±1.78# | |
| CAT (µmol H2O2 consumed/min/ mg protein) | 30.57±0.18 | 13.37±0.26* | 25.17±0.15# | 22.01±0.19# | 10.59±0.26* | 19.12±0.20# | 23.32±0.19# | |
| GPx (n mol NADPH consumed/min/mg protein) | 6.13±0.07 | 3.25±0.06* | 5.77±0.06# | 5.31±0.06# | 2.84±0.04* | 4.59±0.06# | 5.16±0.05# | |
| GR (n mol NADPH consumed/min/mg protein) | 21.02±0.41 | 12.37±0.31* | 18.34±0.38# | 17.86±0.30# | 9.09±0.42* | 14.10±0.21# | 16.91±0.35# | |
| GST (n mol NADPH consumed/min/mg protein) | 34.20±0.30 | 17.04±0.46* | 28.86±0.53# | 25.99±0.35# | 16.37±0.24* | 24.99±0.35# | 30.86±0.53# | |
Values are expressed as mean±SEM, n=6. * indicates significant difference (P<0.05) compared with control group. # indicates significant difference (P<0.05) compared with infected control group.