Table 2. Comparison of kinetic and inhibitory constants of human red cell CA II, native and recombinant Plasmodium falciparum α-carbonic anhydrase (pfCA).

Enzyme	KM (mM)	KCAT (min−1)	KI AZA (nM)	KI SFA(mM)
Human CA II	10.1 ± 0.8	74.1 ± 5.7	99 ± 6	145 ± 2
Native pfCA	3.7 ± 0.2	10.4 ± 1.2	247 ± 14	56 ± 4
Recombinant pfCA	5.6 ± 0.3	8.2 ± 1.6	315 ± 26	84 ±10

AZA and SFA are acetazolamide and sulfanilamide (4-aminobenzenesulfonamide), respectively[59].