Table 2. Repository/Prophylactic activity of ethanolic leaves extract and fractions of M. scadens on P. berghei infection in mice (mean±SEM) (n=6).
Treatment | Dose (mg/kg) | Parasitaemia | % Chemosuppression |
Control (normal saline) | 10 mL/kg | 21.56±1.01 | – |
M. scadens crude extract | 37 | 14.41±0.32* | 33.16 |
74 | 12.88±0.40* | 40.25 | |
111 | 10.40±1.01* | 51.76 | |
Methanol fraction | 74 | 12.15±1.04 | 43.64 |
Ethyl acetate fraction | 74 | 13.54±1.04 | 37.19 |
Chloroform fraction | 74 | 11.20±0.06* | 48.05 |
Pyrimethamine | 1.2 | 8.00±0.42* | 62.89 |
*P<0.001 as compared with the control.