Table 2. Antidiabetic effect of ethanolic leaf extract and fractions of A. djalonensis on blood glucose level of alloxan-induced diabetic rats during acute study (mean±SEM) (n=6).
Treatments | Dose (mg/kg) | Blood glucose level (mg/dL) in hours |
||||
0 h | 1 h | 3 h | 5 h | 7 h | ||
Control | 10 mL | 239.40±8.82 | 251.00±8.39 | 255.00±7.24 | 258.40±6.65 | 254.20±6.26 |
Extract | 37 | 230.90±4.34 | 125.00±5.91 | 43.00±9.24 | 79.40±2.19b | 85.20±2.05b |
74 | 233.40±9.84 | 136.70±5.61c | 37.50±13.86b | 82.60±9.71c | 86.00±8.54c | |
111 | 220.60±10.81 | 113.30±5.73a | 36.00±8.08c | 94.00±5.54c | 95.40±16.00c | |
Chloroform fraction | 74 | 240.60±19.50 | 197.60±2.72a | 34.00±7.37c | 133.30±2.51c | 133.60±2.48c |
Ethyl acetate fraction | 74 | 239.80±19.62 | 227.30±12.74 | 38.30±8.73c | 145.00±9.44b | 150.30±9.73c |
Methanol fraction | 74 | 236.40±21.34 | 204.00±21.60a | 38.66±16.25c | 185.30±20.80c | 184.80±20.70c |
Glibenclamide | 10 | 242.40±4.61 | 239.00±6.24 | 226.60±6.02c | 207.80±9.25c | 197.00±5.47c |
a: P<0.05, b: P<0.01, c: P<0.001 when compared to control.