Table 3. Effect of ethanolic leaf extract and fractions of A. djalonensis on blood glucose level of alloxan-induced diabetic rats during prolonged treatment (mean±SEM) (n=6).
Treatments | Dose in (mg/kg) | Blood glucose level (mg/dL) in days |
||||||
Day 0 | Day 1 | Day 3 | Day 5 | Day 6 | Day 7 | Day 15 | ||
Control | 10 mL | 239.40±8.82 | 240.20±3.41 | 252.40±5.64 | 258.20±6.01 | 239.20±7.69 | 232.60±5.31 | 224.20±3.56 |
Extract | 37 | 230.90±4.34 | 33.20±9.29 | 125.40±4.00 | 94.00±17.34a | 59.40±10.20a | 61.00±7.93a | 39.20±10.96a |
74 | 233.40±9.84 | 40.00±20.80 | 90.00±13.0 | 79.30±10.40a | 64.20±16.01a | 97.80±3.74a | 51.30±14.01a | |
111 | 220.60±10.81 | 54.40±23.86 | 110.60±11.84 | 67.50±4.16a | 56.00±2.00a | 64.40±11.54a | 32.00±7.21a | |
Chloroform fraction | 74 | 240.60±19.50 | 204.30±23.10 | 93.70±10.63 | 93.00±32.0a | 57.60±1.52a | 60.00±14.73a | 33.20±6.50a |
Ethyl acetate fraction | 74 | 239.80±19.62 | 125.60±9.70 | 172.30±13.55 | 182.00±19.82a | 51.70±11.50a | 58.70±15.37a | 44.00±12.16a |
Methanol fraction | 74 | 236.40±21.34 | 82.33±17.55 | 213.60±21.76 | 149.80±10.16a | 55.00±8.54a | 69.00±13.45a | 36.00±6.08a |
Glibenclamide | 10 | 242.40±4.61 | 208.30±9.25 | 176.30±7.86 | 135.80±11.30a | 86.00±10.79a | 73.60±7.36a | 59.60±6.80a |
a: P<0.001 when compared to control.