Table 2.
Differences at baseline in skeletal muscle VEGF concentration, number of capillaries/fiber and capillaries/mm2, and peak VO2 among control and PAD subjects
| VEGF-A | VEGFl65b | VEGF-R1 | Capillary supply | Capillary supply | Peak VO2 | |
|---|---|---|---|---|---|---|
|
| ||||||
| pg VEGF-A/mg protein | pg VEGFl65b/mg protein | pg VEGF-R1/mg protein | Capillaries/mm2 | Capillaries/fiber | ml/kg/min | |
| Control | 116.5 ± 56.6 | 2120.6 ± 819.1 | 508.6 ± 313.8* | 317.6 ± 87.2* | 2.2 ± 0.7* | 25.6 ± 6.6* |
| n = 30 | n = 14 | n = 28 | n = 26 | n = 26 | n = 29 | |
| PAD | 119.3 ± 73.9 | 1720.1 ± 743.5 | 177.3 ± 133.3 | 247.7 ± 69.8 | 1.8 ± 0.6 | 16.9 ± 4.2 |
| n = 22 | n = 17 | n = 20 | n = 22 | n = 22 | n = 22 | |
p < 0.05 between control and PAD patients.
PAD, peripheral artery disease; peak VO2, peak oxygen consumption; pg, picogram; VEGF, vascular endothelial growth factor; VEGF-R1, vascular endothelial growth factor receptor 1.