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. Author manuscript; available in PMC: 2013 Mar 27.
Published in final edited form as: Hear Res. 2011 Dec 24;284(1-2):42–51. doi: 10.1016/j.heares.2011.12.006

Figure.9. Schematic representation of the proposed hypothesis.

Figure.9

that Hcy induces matrix imbalance in the cochlear tissue which then affects hearing thresh holds. Hcy also induces oxidative stress in the cochlear tissue, in part, by down regulating levels of p22phox and p47phox subunits this in-turn decreases hearing threshold. Folic acid treatment alleviates Hcy induced decrease hearing threshold, by down regulating Hcy-induced oxidative stress, via declining collagen turnover and matrix imbalance.