Table 1. Examples of high content datasets and associated publications in the nuclear receptor signaling field.

Examples of high content datasets and associated publications in the nuclear receptor signaling field. Literature references for transcriptomics and cistromics of NR & NR ligand target genes can be found in the Transcriptomics and Cistromics section of specific Molecule Pages on the NURSA website (www.nursa.org).

System	Subsystem	Technique	Species	Tissue/context	References
Transcriptomic	NRs	Q-PCR	M. musculus	Multiple adult	[19]
			M. musculus	Metabolic circadian	[20]
			H. sapiens	Activated macrophages	[29]
			M. musculus	Adipogenesis in 3T3L1 cells	[34]
			M. musculus	Adult brain	[24]
			M. musculus	Osteoblasts, osteogenesis v adipogenesis	[23]
			M. musculus	Development	[21]
			M. musculus	Adult endocrine pancreas	[22]
			H. sapiens	Cancer cell lines	[30]
			H. sapiens	HeLa and HepG2 cells	[25]
			M. musculus & H. sapiens	Embryonic stem cells	[59]
	Coregulators	Q-PCR	M. musculus	Multiple adult	[60]
	NR & NR ligand target genes	Expression microarray	Multiple	Multiple	See Legend
	Coregulator target genes	Expression microarray	M. musculus	Livers of SRC null mutants	[61]
GWLA (Cistromics)	NR & NR ligand target genes	ChIP-chip and ChIP-seq	Multiple	Multiple	See Legend
	Coregulator target genes	ChIP-chip and ChIP-seq	H. sapiens	SRC-3 in 17β-estradiol stimulated MCF-7 cells	[45]
Proteomic	Coregulator-coregulator	Affinity purification-mass spectrometry	H. sapiens	HeLa cells	In Press
		YTH/in silico	Multiple	Multiple	[31]
	NR-coregulator	Affinity purification-mass spectrometry	H. sapiens	ERα-SRC-3 in 17β-estradiol stimulated MCF-7 cells	[45]
Metabolomic	NR	Mass spectrometry	M. musculus	NR models of diabetes and fatty liver disease
	Coregulator	Mass spectrometry	M. musculus	Livers of SRC-2 null mutants	[44]