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. 2013 Mar 14;62(4):1206–1216. doi: 10.2337/db12-0314

FIG. 6.

FIG. 6.

PGC-1α overexpression during fetal life only is sufficient to impair β-cell function. A: β-Cell fraction was morphometrically measured on pancreatic sections from control (white bars) and Ins-PGC-1α (black bars) newborn mice. B: PGC-1α mRNA levels in pancreata of control (white bars) and Ins-PGC-1α (black bars) mice at postnatal day 1 (P1) and 21 (P21, left to right) upon Dox treatment from birth. C: PGC-1α and β-cell genes mRNA levels in islets and β-cell mass of 4-month-old control (white bars) and Ins-PGC-1α (black bars) mice upon Dox treatment from birth. D: IpGTT performed on 4-month-old Ins-PGC-1α (black triangles) compared with control (white circles) mice under Dox treatment from birth. Inset shows the area under the curve for 0–120 min of plasma glucose of these mice. E: Serum insulin levels before and 15 min after intraperitoneal glucose injection in control (white bars) and Ins-PGC-1α (black bars) mice. F: β-Cell mass of control (white bars) and Ins-PGC-1α (black bars) mice. All values are means ± SD. *P < 0.05, **P < 0.01 when comparing control with Ins-PGC-1α mice using a Mann-Whitney nonparametric test (n = 5 per group).