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. 2013 Mar 14;62(4):1139–1151. doi: 10.2337/db12-0491

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 5. — A: Contraction-stimulated 2DG uptake in soleus and EDL without or with 200 μmol/L NSC23766, 1-h preincubation (n = 12). B: Contraction-stimulated 2DG uptake in soleus and EDL without or with 10 μmol/L Rac1 Inhibitor II (Inhib II), 1-h preincubation (n = 10). C: Representative blots and bar graphs show contraction-stimulated p-AMPK^Thr172 and p-ACC^Ser212 in soleus and EDL muscle without or with 200 μmol/L NSC23766. D: Representative blots and bar graphs show contraction-stimulated p-AMPK^Thr172, p-ACC^Ser212, and p-PAK^Thr423 signaling and Rac1 and GLUT4 total protein in soleus and EDL muscle without or with 10 μmol/L Rac1 Inhibitor II (Inhib II). E: Insulin-stimulated (60 nmol/L) 2DG uptake in mouse white adipose (gonadal) tissue without or with 10 μmol/L Rac1 Inhibitor II (Inhib II), 1-h preincubation (n = 8). Statistical significance between basal and contraction is indicated by *P < 0.05; **P < 0.01; ***P < 0.001. Effect of inhibitor on contraction-stimulated 2DG or p-PAK^Thr423 is indicated by #P < 0.05; ##P < 0.01; ###P < 0.001. Main effect of inhibitor is indicated by †P < 0.05. Values represent mean ± SEM.

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