Table 1.
Days after transduction | MOI | hFIX protein (ng) per 105 cells | Cumulative number of cells (×105) | hFIX protein (ng) from cumulative cells |
---|---|---|---|---|
4 | 1 | 21.28±5.30 | 2.93±0.60 | 60.37±3.24a |
5 | 261.57±45.23 | 2.08±0.33 | 535.49±37.69a | |
10 | 494.99±93.79 | 1.73±0.20 | 843.84±65.40a | |
30 | N/A | N/A | N/A | |
8 | 1 | 27.81±5.08 | 4.15±1.15 | 111.63±14.45a |
5 | 245.23±59.24 | 2.71±0.74 | 641.15±80.28a | |
10 | 383.78±80.05 | 2.40±0.80 | 885.83±138.03a | |
30 | N/A | N/A | N/A | |
19 | 1 | 9.57±2.58 | 6.26±1.72 | 57.87±11.86a |
5 | 81.26±22.14 | 4.15±1.77 | 316.31±93.21 | |
10 | 103.46±20.32 | 3.06±0.54 | 324.15±124.48 | |
30 | N/A | N/A | N/A | |
28 | 1 | 24.52±13.76 | 12.03±3.89 | 270.87±128.77 |
5 | 119.49±42.86 | 5.94±2.11 | 744.11±493.55 | |
10 | 148.97±49.51 | 5.05±0.78 | 762.32±326.91 | |
30 | 514.50±191.43 | 1.03±0.42 | 478.57±42.42 |
hFIX, human factor IX; MOI, multiplicity of infection; N/A, not applicable.
Note: Data are expressed as mean values±SD.
p<0.05 versus the other groups in the same day after transduction (n=3).