Table 2.
Performance of the Array-Based Mutation Detection Method for Predicting NPM1 Mutations on the Training and Validation Cohorts
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95% CI |
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95% CI |
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| Dataset | n | TP | FP | TN | FN | Sens | LL | UL | Spec | LL | UL |
| Training data | 505 | 145 | 0 | 360 | 0 | 100.0 | 97.4 | 100.0 | 100.0 | 98.9 | 100.0 |
| Validation data | 143 | 66 | 2a | 75 | 0 | 100.0 | 94.5 | 100.0 | 97.4 | 91.0 | 99.3 |
a
Sequencing of the hybridization cocktails confirmed one case to be NPM1 A, and the other to be a non-ABD mutant. This results in 67 TP and 1 FP, corresponding with a sensitivity of 100.0 (95% CI 94.6–100.0) and specificity of 98.7 (95% CI 92.9–99.8).
TP, true positive; FP, false positive; TN, true negative; FN, false negative; CI, confidence interval.