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Graphical review of the experimental design. LhCG is transduced with Ad-SDF and implanted subcutaneously into nude mice. Released SDF-1 circulates in the blood and attracts the CD34+ stem cells against the concentration gradient. The stem cells will trespass the endothelium and basal lamina and home to the graft site for therapeutic purpose. SDF-1, stromal cell-derived factor-1; LhCG, living hyaline cartilage graft. Color images available online at www.liebertpub.com/tea
