Table 2.
Distribution of Allelic and Genotypic Frequencies of CTLA 4 Exon 1+49 A/G SNP in Four Tested Cohorts
| Case (n) | Allele | Case no. (f) | Control no. (f) | Chi square | p-Value |
|---|---|---|---|---|---|
| SLE (472) | A | 382 (0.81) | 0.21 | 0.65 | |
| G | 90 (0.19) | ||||
| RA (228) | A | 178 (0.78) | A-450 (0.8) | 0.29 | 0.59 |
| G | 50 (0.22) | G-114 (0.2) | |||
| OP (76) | A | 60 (0.79) | 0.03 | 0.86 | |
| G | 16 (0.21) |
| Case (n) | Genotype | Case no. (f) | Control no. (f) | Chi square | p-Value |
|---|---|---|---|---|---|
| SLE (236) | AA | 152 (0.64) | 0 | 1 | |
| RA (114) | 74 (0.65) | 182 (0.65) | 0 | 1 | |
| OP (38) | 24 (0.63) | 0.03 | 0.86 | ||
| SLE (236) | 78 (0.33) | 0.39 | 0.53 | ||
| RA (114) | AG | 30 (0.26) | 86 (0.31) | 0.69 | 0.4 |
| OP (38) | 12 (0.32) | 0.02 | 0.89 | ||
| SLE (236) | 6 (0.03) | 2.03 | 0.15 | ||
| RA (114) | GG | 10 (0.09) | 14 (0.05) | 2.07 | 0.15 |
| OP (38) | 2 (0.05) | 0.006 | 0.94 |
OP, overlapping.