Figure 6.

The incidence of hepatocellualr adenoma, detected under microscopy, in diethylnitrosamine-injected rats after 10 months of ethanol exposure with or without CMZ treatment. Hepatocellualr adenoma, under H&E staining (upper panel ×40, lower panel ×400). The tumor (indicated by arrow) is composed of sheets of hepatocytes that are larger than those of the surrounding liver, which shows compression. All rats were injected with DEN (20 mg/kg BW) and treated with either a non-ethanol (C) or an ethanol diet (E) with or without two doses (10- and 100-mg/kg BW) of CMZ supplementation for 10 months