Table 3.
Relative risk of ALS in full siblings and children of proband ALS cases, compared to risk of ALS in a reference population, stratified by sex and age at follow-up of the relatives, Sweden, 1961-2005
| Cases | Person-years | RR* | 95% CI† | ||
|---|---|---|---|---|---|
| Sex | |||||
| Men | Reference | 3,870 | 172,158,921 | 1.0 | |
| Exposed | 26 | 117,282 | 9.2 | 6.1-13.2 | |
| Women | Reference | 2,776 | 169,012,087 | 1.0 | |
| Exposed | 20 | 112,356 | 10.6 | 6.6-16.0 | |
| Attained age at follow-up | |||||
| ≤44 years | Reference | 356 | 229,457,636 | 1.0 | |
| Exposed | 4 | 109,956 | 20.9 | 6.4-48.9 | |
| 45-54 years | Reference | 668 | 41,440,002 | 1.0 | |
| Exposed | 18 | 70,126 | 15.2 | 9.1-23.6 | |
| 55-64 years | Reference | 1,629 | 33,433,610 | 1.0 | |
| Exposed | 16 | 41,769 | 7.3 | 4.2-11.5 | |
| ≥65 years | Reference | 3,993 | 36,839,760 | 1.0 | |
|
|
Exposed |
8 |
7,787 |
8.4 |
3.8-15.6 |
*
Relative risk, derived from multivariable Poisson regression models, adjusted for age, sex, and calendar period.
†
Confidence interval.