Table 3. Risk of developing major depression and any depressive disorder among women with symptomatic menopausal transition (n = 5837) compared to the control group (n = 23,348).

	Major depression			Any depressive disorder
	HR	95%CI	p	HR	95%CI	p
Symptomatic menopausal transition	2.18	1.79∼2.65	<0.001	2.34	2.08∼2.63	<0.001
Age at enrollment	0.99	0.98∼1.00	0.057	0.99	0.98∼1.00	0.006
Medical comorbidities during the whole follow-up period
Diabetes mellitus	1.13	0.90∼1.41	0.289	1.11	0.97∼1.27	0.125
Congestive heart failure	1.27	0.82∼1.98	0.285	1.35	1.04∼1.75	0.026
Chronic renal diseases	1.18	0.86∼1.64	0.311	1.16	0.96∼1.41	0.132
Liver diseases	1.18	0.94∼1.47	0.163	1.19	1.03∼1.36	0.015
Rheumatological diseases	1.04	0.607∼1.78	0.891	1.33	0.99∼1.79	0.057
Cerebrovascular disease	1.74	1.35∼2.24	<0.001	1.77	1.52∼2.07	<0.001
Coronary artery disease	1.23	0.95∼1.60	0.121	1.35	1.15∼1.57	<0.001
Residence location
Northern	1	–	–	1	–	–
Middle	0.91	0.67∼1.25	0.568	1.21	1.01∼1.44	0.039
Southern	1.41	1.12∼1.77	0.004	1.51	1.32∼1.74	<0.001
Eastern	1.72	1.12∼2.64	0.014	1.19	0.88∼1.60	0.260
Level of urbanization
1 (most urban)	1	–	–	1	–	–
2	0.89	0.69∼1.13	0.333	0.97	0.83∼1.12	0.641
3	0.88	0.64∼1.19	0.394	0.79	0.65∼0.95	0.014
4	0.84	0.60∼1.17	0.291	0.85	0.70∼1.04	0.112
5 (most rural)	0.67	0.45∼1.01	0.055	0.75	0.59∼0.96	0.020
Income-related insured amount
<20,000NTD/month	1	–	–	1	–	–
20,000∼39,999NTD/month	0.81	0.66∼1.01	0.059	0.86	0.76∼0.98	0.026
≥40,000NTD/month	0.63	0.42∼0.94	0.023	0.84	0.67∼1.05	0.841

Major depression: 296.2X and 296.3X.

Any depressive disorder: 296.2X, 296.3X, 300.4, and 311.

HR: hazard ratio; 95% CI: 95% confidence interval.