Figure 3. Histological outcomes.

A, Tissue sparing measures in SCI research are typically taken at the lesion center as determined by the largest extent of the lesion ellipsoid. Although specific methods for quantification may vary across studies, typical measures include lesion size, B, gray matter (GM) sparing, C, white matter (WM) sparing, D, total sparing (GM+WM), E, total tissue area (GM+WM+debris), F, motorneuron number. Scale bar, 100 µm. Since the compiled dataset was limited to unilateral injuries (hemisections or hemicontusions), all measures are represented as a percentage of the contralateral, spared hemicord. The quantified area is illustrated in red on a representative example. The representative example was taken from the subject closest to the group mean for lesion size across the study’s 159 subjects.