Table 3. Fold change in cytokine expression levels.
Cytokine/chemokine | Fold change (N1/N2) | p-value (N1 vs. N2) | Fold change (MGUS/N2) | p-value (MGUS vs. N2) | Fold change (MM/N2) | p-value (MM vs. N2) | Fold change (MGUS/MM) | p-value (MGUS vs. MM) |
IL-1β | 0.30 | >0.05 | 0.12 | >0.05 | 0.54 | >0.05 | 0.22 | >0.05 |
IL-1ra | 0.29 | 0.0002 | 0.08 | 0.0018 | 0.30 | <0.0001 | 0.27 | >0.05 |
IL-2 | 0.21 | >0.05 | 0.03 | >0.05 | 0.44 | >0.05 | 0.08 | >0.05 |
sIL-2R | 0.46 | <0.0001 | 1.69 | >0.05 | 1.46 | 0.0002 | 1.16 | >0.05 |
IL-3 | ND | ND | 0.03 | 0.01 | 0.23 | 0.0064 | 0.14 | >0.05 |
IL-4 | 4.67 | <0.0001 | 2.18 | 0.0012 | 3.30 | <0.0001 | 0.66 | >0.05 |
IL-5 | 4.69 | <0.0001 | 0.48 | >0.05 | 0.75 | >0.05 | 0.65 | >0.05 |
IL-6 | 0.38 | 0.0276 | 0.47 | >0.05 | 0.33 | >0.05 | 1.44 | >0.05 |
IL-7 | 0.58 | <0.0001 | 1.42 | 0.0014 | 1.28 | <0.0001 | 1.11 | >0.05 |
IL-8 | 0.17 | <0.0001 | 1.06 | >0.05 | 1.46 | >0.05 | 0.73 | >0.05 |
IL-10 | 2.14 | 0.0028 | 1.59 | >0.05 | 1.94 | <0.0001 | 0.82 | >0.05 |
IL-12 | 0.37 | <0.0001 | 0.53 | >0.05 | 1.03 | >0.05 | 0.51 | >0.05 |
IL-13 | 1.09 | >0.05 | 0.02 | <0.0001 | 0.02 | <0.0001 | 0.78 | >0.05 |
IL-15 | 3.17 | 0.0001 | 0.74 | >0.05 | 1.95 | >0.05 | 0.38 | >0.05 |
IL-17 | 6.90 | <0.0001 | 0.18 | >0.05 | 5.87 | <0.0001 | 0.03 | 0.0049 |
Eotaxin | 0.71 | 0.0006 | 1.36 | 0.0354 | 1.46 | 0.0083 | 0.93 | >0.05 |
GM-CSF | 2.28 | >0.05 | 0.02 | <0.0001 | 0.19 | <0.0001 | 0.10 | >0.05 |
IFNα | 4.89 | <0.0001 | 0.74 | >0.05 | 1.17 | >0.05 | 0.63 | >0.05 |
IFNγ | 1.14 | >0.05 | 0.07 | <0.0001 | 0.13 | <0.0001 | 0.51 | >0.05 |
IP-10 | 0.15 | <0.0001 | 1.02 | >0.05 | 1.37 | >0.05 | 0.74 | >0.05 |
MCP-1 | 0.12 | <0.0001 | 1.11 | >0.05 | 1.45 | 0.0027 | 0.76 | >0.05 |
MIG | 0.62 | 0.0251 | 0.63 | >0.05 | 0.56 | 0.0021 | 1.12 | >0.05 |
MIP-1α | 0.38 | <0.0001 | 0.43 | >0.05 | 1.25 | >0.05 | 0.35 | >0.05 |
MIP-1β | 1.82 | >0.05 | 1.08 | >0.05 | 0.86 | >0.05 | 1.26 | >0.05 |
RANTES | 0.60 | >0.05 | 0.49 | >0.05 | 0.71 | >0.05 | 0.69 | >0.05 |
TGFβ2 | ND | ND | 0.36 | >0.05 | 2.03 | >0.05 | 0.18 | >0.05 |
TNFα | 2.92 | 0.0011 | 0.34 | >0.05 | 0.82 | >0.05 | 0.41 | >0.05 |