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. 2013 Mar 27;8(3):e59075. doi: 10.1371/journal.pone.0059075

Figure 3. Stress and corticosterone administered 12 h after fear memory retrieval selectively impaired the persistence but not formation of long-term memory.

Figure 3

(A) Rats were exposed to cold water stress or administered corticosterone 1, 12, or 24 h after retrieval of the memory of strong contextual fear conditioning (CFC) and then tested for long-term memory (LTM) on day 2 and day 7. (B) Stress exposure 1 h after CFC retrieval enhanced LTM reformation tested on day 2, whereas stress exposure 12 h after CFC retrieval selectively enhanced the persistence of LTM tested on day 7 but did not affect LTM reformation tested on day 2. (C) Corticosterone administration 1 h after CFC retrieval enhanced LTM formation tested on day 2, whereas corticosterone administration 12 h after CFC retrieval selectively enhanced the persistence of LTM tested on day 7 but did not affect LTM reformation tested on day 2. The data are expressed as mean ± SEM (n = 6–8 per group). *p<0.05, compared with Control group.