Table 1. Areas under the curve during IPGTT.
Control | Pair-fed | EtOH | EtOH+T | |
Glucose curve (mmol.min/l) | ||||
Early | 914±40 | 872±45 | 1121±54*## | 923±47 |
Mid | 839±54 | 870±28 | 1078±42**### | 896±42 |
Late | 923±40 | 867±51 | 1180±62**## | 932±72 |
Insulin curve (ng.min/ml) | ||||
Early | 190±9 | 205±6 | 285±17***### | 222±9 |
Mid | 161±12 | 164±8 | 240±21*## | 185±16 |
Late | 223±12 | 218±15 | 296±21*# | 233±21 |
Four month-old male rat offspring were exposed to ethanol (EtOH) or water only during early, mid, or late pregnancy. Control and pair-fed offspring were from dams with free access to chow and dams fed the amount of chow consumed by EtOH dams, respectively. A subgroup of EtOH rats was given TUDCA (T) 3 weeks before the experiments. Data are the mean±SE, n = 6. *P<0.05, **P<0.01, ***P<0.001 EtOH vs. control; #P<0.05, ##P<0.01, ###P<0.001 EtOH vs. pair-fed.