Table 5. Genotypic analyses of SNPs with Cutaneous Melanoma risk association.
Non-adjusted | Adjusted* | Enlarged sample | |||||
SNP | Statistical model | OR (CI 95%) | p-value | OR (CI 95%) | p-value | OR (CI 95%) | p-value |
rs12512631 | Genotypic | 1.29 (1.04–1.60) | 0.019 | 1.32 (1.01–1.72) | 0.041 | 1.11 (0.96–1.28) | 0.153 |
Dominant | 1.63 (1.23–2.17) | 7×10 −4 | 1.71 (1.20–2.45) | 3×10 −3 | 1.28 (1.05–1.56) | 0.012 | |
Recessive | 0.94 (0.61–1.45) | 0.774 | 0.94 (0.55–1.60) | 0.809 | 0.90 (0.68–1.19) | 0.458 | |
rs222016 | Genotypic | 1.30 (0.95–1.77) | 0.102 | 1.23 (0.83–1.82) | 0.312 | 1.11 (0.92–1.35) | 0.277 |
Dominant | 1.37 (0.98–1.93) | 0.068 | 1.30 (0.85–1.98) | 0.222 | 1.22 (0.97–1.52) | 0.083 | |
Recessive | 0.95 (0.31–2.93) | 0.929 | 0.65 (0.14–3.09) | 0.586 | 0.65 (0.35–1.20) | 0.168 |
Bold denotes statistically significant results.
OR (CI 95%) means Odds Ratio and its 95% confidence interval.
Adjusted for eye colour, hair colour, skin colour, lentigines, number of naevi and childhood sunburn.
The enlarged sample makes a total of 684 controls and 1045 cases.