Figure 1. Possible mechanisms of action of PI3Kγ inhibitor AS-605240 in mediating resistance to L. mexicana infection: (1) prevent migration of neutrophils and macrophages to L mexicana infected sites;, (2) block phagocytosis of L mexicana promastigotes by neutrophils and macrophages; (3) inhibit migration of IL-10 producing regulatory T cells to infected areas which would otherwise dampen the immune response; (4) indirectly prevent production of Th-2 associated cytokines IL-4 and IL-10; and (5) directly or indirectly suppress the production of serum antibodies which could otherwise contribute to Fc receptor mediated internalization of L. mexicana parasites.