Table 4. P. aeruginosa strains exhibit increased susceptibilities to vancomycin and erythromycin upon treatment with PAβN.
| Minimum Inhibitory Concentrations (µg/mL)a | ||||||||
| Vancomycin | Erythromycin | |||||||
| [PAβN] (µg/mL) | [PAβN] (µg/mL) | |||||||
| Strain | 0 | 10 | 25 | 50 | 0 | 10 | 25 | 50 |
| PAO1 | >256 (>256) | >256 (>256) | 96 (>256) | 32 (>256) | 64 (96) | 64 (96) | 16 (64) | 4 (8) |
| dacB | >256 (>256) | >256 (>256) | 96 (>256) | 32 (>256) | 64 (96) | 64 (96) | 24 (64) | 6 (12) |
| Δefflux | >256 (>256) | >256 (>256) | N/A | N/A | 3 (4) | 1.5 (2) | N/A | N/A |
a
MICs shown in parentheses were obtained with 1 mM MgSO4 in the assay.
N/A; efflux-deficient bacteria do not grow on Mueller-Hinton agar containing 25, or 50 µg/mL PAβN with or without 1 mM MgSO4.