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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Stroke. 2013 Feb 7;44(4):1135–1143. doi: 10.1161/STROKEAHA.111.000633

Figure 3. Simvastatin reduces brain IFNγ protein expression and brain damage contributed by splenic cells.

Figure 3

Figure 3

Figure 3

Figure 3

Splenectomy and adoptive transfer of splenocytes were performed as described in the Method. Stroke analysis was performed 5 days after MCAO. A, Representative images of cresyl violet-stained coronal brain sections (upper) and Quantitative analysis of infarct volumes (lower). Scale bar = 2 mm. B, The 28-point neurological scoring at indicated time points (n= 6-8 survived mice/group). *P<0.05 vs. sham-splenectomized MCAO mice; #P<0.05 vs. splenectomized MCAO mice, and &P<0.05 vs. splenectomized MCAO mice with adoptive transfer of splenic cells (SC) at the same time point. C and D, ELISA measurement of IFN-γ protein concentrations in the ipsilateral hemispheres from the indicated groups at 72h after MCAO. n=5 mice/group.