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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Psychoneuroendocrinology. 2012 Dec 4;38(7):1158–1169. doi: 10.1016/j.psyneuen.2012.11.004

Figure 7. Effects of the STAT3 phosphorylation inhibitor JSI-124 on plasma CORT, plasma ACTH and hypothalamic P-STAT3 levels in CIC stressed animals.

Figure 7

Rats received constant ICV infusions of either a STAT3 phosphorylation inhibitor, JSI-124, or vehicle and were subjected to 1 or 14 days CIC. No Stress animals are indicated by NS. All groups received the drug treatments for the same length of time. Rats were sacrificed at the end of 6h cold exposure. CORT (panel A, n=5-6) and ACTH (panel B, n=5-6) were measured in the plasma and P-STAT3 levels (panel C, n=5-8) were measured in hypothalamus lysates. * significantly different from NS within the same drug treatment, # significantly different from CIC-14d VEH, $ significant Main Effect of Drug, p<0.05,Newman-Keuls post-hoc test.