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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Laryngoscope. 2013 Mar 11;123(4):992–999. doi: 10.1002/lary.22171

Figure 3.

Figure 3

Effect of ototoxin treatment and delivery of Ad28.gfap.atoh1 on hearing. Adult mice were tested for hearing loss prior to administration of aminoglycosides and diuretic. Treatment with kanamycin and furosemide resulted in a reduction of hearing thresholds to and average of 100 dB in all frequencies tested in both the left and right ears. Two months after delivery of Ad28.gfap.atoh1 to the left ear there was a moderate recovery of hearing at 4 and 8 kHz. There was no recovery in the right, non vector treated ear. Difference in hearing at 4 and 8 kHz was statistically significant (p<0.01) when comparing the left and right sides. There was no significant difference in hearing at 16 or 32 kHz when comparing the treated to the untreated side.