Table 6.
Comparison of myotonic dystrophy to controls on measures of fractional anisotropy (FA) and mean diffusion (MD) in whole cerebrum and five regions of interest.
| Control (n = 15) | Myotonic Dystrophy (n =16) | Statistical tests | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Mean | SD | Mean | SD | t | p | Effect size (Cohen’s d) | |
| Fractional Anisotropy (FA) | |||||||
| Whole cerebrum | .372 | .013 | .334 | .021 | 6.00 | <.00001* | 2.2 |
| Frontal lobe | .336 | .012 | .297 | .019 | 7.01 | <.00001* | 2.5 |
| Temporal lobe | .322 | .016 | .286 | .023 | 4.92 | =.00003* | 1.8 |
| Parietal lobe | .359 | .016 | .318 | .027 | 5.02 | =.00002* | 1.8 |
| Occipital lobe | .298 | .019 | .261 | .024 | 4.72 | =.00006* | 1.7 |
| Corpus callosum | .606 | .032 | .586 | .046 | 1.42 | =.16626 | 0.5 |
| Mean Diffusivity (MD) | |||||||
| Whole cerebrum | .800 | .017 | .872 | .030 | 8.20 | <.00001* | 3.0 |
| Frontal lobe | .782 | .018 | .856 | .030 | 8.25 | <.00001* | 3.0 |
| Temporal lobe | .846 | .017 | .927 | .027 | 9.95 | <.00001* | 3.6 |
| Parietal lobe | .785 | .017 | .856 | .030 | 8.00 | <.00001* | 2.9 |
| Occipital lobe | .769 | .015 | .835 | .038 | 6.25 | <.00001* | 2.3 |
| Corpus callosum | 1.04 | .068 | 1.12 | .104 | 2.45 | =.01989* | 0.9 |
NOTES: Mean Diffusivity values are ×10−6 mm2/second.
*
= significant at p<.05 level