. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Br J Haematol. 2012 Dec 17;160(4):547–554. doi: 10.1111/bjh.12167

Table II.

Performance characteristics of eADA in DBA patients vs. DBA relatives and Non-DBA patients and relatives

Increased eADA^†				Performance Characteristics
DBA patients	DBA relatives	Non-DBA patients	Non-DBA patients and relatives	OR	95% CI	Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)
31/37	5^*/68			70	17–304	84	93	92	86
31/37		3/64		105	21–632	84	95	91	91
31/37			3/77	132	27–793	84	96	93	91

OR indicates odds ratio in favour of being a DBA patient; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; DBA, Diamond-Blackfan anaemia; eADA, erythrocyte adenosine deaminase.

^†

Data and number of patients of individuals with increased ADA/number analysed.

These individuals did not meet the diagnostic criteria of DBA as described in the methods section.