Fig. 4.

miR-10b regulates GBM cell and stem cell invasion. GBM cells (SF767 and T98G), GSCs (0308, 0822 and 1228), and astrocytes were transfected with anti-miR-10b or anti-miR-Contol (20 nM) for 24 h. GBM SF767 cells were transfected with miR-10b or miR-cont (20 nM) for 24 h. Cell invasion was assessed using a transwell assay. a The results show that mir-10b inhibition inhibits the invasion of astrocytes, SF767 and T98G cells, b as well as 0308, 0822 and 1228 GSCs. c The invasion inhibition is significantly higher in GSCs than GBM cells. d The results also show that miR-10b overexpression significantly increases the invasion in GBM cells