Figure 2. Efficacy of oral b240 administration in CA04-infected mice.

Mice were administered heat-killed b240 at a dose of 10 mg/mouse daily for 21 days prior to infection and for 14 days after infection. Mice in the control group received saline. They were then intranasally infected with 0.3 or 10 MLD₅₀ of mouse-adapted CA04 virus on day 21 post-b240 administration. Mortality and morbidity were monitored daily for 14 days post-infection. Percent survival (a) and body weight (c) are shown for each group of ten mice infected with 0.3 MLD₅₀ of virus. Percent survival (b) and body weight (d) are shown for b240- or saline-treated groups of 24 or 25 mice infected with 10 MLD₅₀ of virus, respectively. The body weight values are means ± SD for the mice that were alive at each time point. Asterisk: P value < 0.05, significant difference compared to the virus-infected group not treated with b240 (log-rank test).