Table 2. Histological examination of the lungs of mice.
| Days | 1 | 3 | 6 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| #* | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| b240 | ++/++ | +++/+++ | ++/++ | +++/+++ | ++/++ | +++/+++ | +++/+++ | +++/+++ | +++/+++ |
| saline | ++/++ | +++/+++ | +++/+++ | +++/+++ | +++/+++ | +++/+++ | +++/+++ | +++/+++ | ND† |
Nine mice per group were infected with 10 MLD50 of CA04 virus and three mice per group were euthanized on days 1, 3, and 6 post-infection. The extent of pneumonia and viral antigen expression was evaluated by using a distribution scoring system. 0%, -; 0% < 40%, +; 40% < 60%, ++; and 60% < 100%, +++.
*The number of the individual animals.
†Not determined.