Table 3. Top GO terms enriched by genes that were significantly differentially expressed following oral administration of b240 in the lungs of uninfected mice.

GO term	P value	Molecules
Palmitoyl-CoA Hydrolase Activity	0.001	Acot1↓, Acot2↓, Acot5↓
Thioester Metabolic Process	0.001	Acot1↓, Acot2↓, Acot5↓
Acyl-CoA Thioesterase Activity	0.001	Acot1↓, Acot2↓, Acot5↓
Acyl-CoA Metabolic Process	0.001	Acot1↓, Acot2↓, Acot5↓
CoA Hydrolase Activity	0.001	Acot1↓, Acot2↓, Acot5↓
Carboxylesterase Activity	0.002	Acot1↓, Acot2↓, Acot5↓, Lipe↓
Response to Protein Stimulus	0.037	Cyr61↓, Egr1↓, Fos↓

Genes statistically significantly regulated in the lungs of uninfected mice treated with b240 compared with saline-treated mice were determined by using two-way ANOVA (Fold change > 1.5, P < 0.05). The set of genes differentially regulated by b240 administration was functionally annotated by means of GO grouping. Statistical significance was determined by using Fisher's exact test (P < 0.05). Arrows next to each gene name indicate the up- or down-regulation induced by b240 administration.