Table 4. Top ingenuity canonical pathways enriched by genes that were significantly differentially expressed following oral administration of b240 in the lungs of uninfected mice.

Ingenuity Canonical Pathways	P value	Ratio	Molecules
Circadian Rhythm Signaling	0.001	0.057 (2/35)	Per3↑, Arntl↓
IL-17A Signaling in Fibroblasts	0.001	0.050 (2/40)	Fos↓, Nfkbiz↓
IGF-1 Signaling	0.006	0.019 (2/107)	Fos↓, Cyr61↓
Role of Tissue Factor in Cancer	0.008	0.018 (2/114)	Egr1↓, Cyr61↓
GNRH Signaling	0.010	0.014 (2/145)	Fos↓, Egr1↓
AMPK Signaling	0.011	0.012 (2/166)	Cpt1a↓, Lipe↓
CXCR4 Signaling	0.014	0.012 (2/169)	Fos↓, Egr1↓
RAR Activation	0.018	0.011 (2/183)	Fos↓, Pnrc1↓
Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza	0.029	0.036 (1/28)	Rsad2↑
IL-17A Signaling in Gastric Cells	0.030	0.040 (1/25)	Fos↓
TNFR2 Signaling	0.035	0.029 (1/34)	Fos↓
April Mediated Signaling	0.045	0.023 (1/43)	Fos↓
B Cell Activating Factor Signaling	0.047	0.022 (1/45)	Fos↓
MIF Regulation of Innate Immunity	0.048	0.020 (1/50)	Fos↓

Genes statistically significantly regulated in the lungs of uninfected mice treated with b240 compared with saline-treated mice were determined by using two-way ANOVA (Fold change > 1.5, P < 0.05). Functional enrichment analysis for the set of genes differentially regulated by b240 administration was determined by using IPA software. Statistical significance was determined by using Fisher's exact test (P < 0.05). Arrows next to each gene name indicate the up- or down-regulation induced by b240 administration.