Table 3.
Changes in TSQM, 6MWD, medication administration time, and adverse events associated with transitioning from inhaled iloprost to inhaled treprostinil
| Baseline | Week 12 | Absolute change | Standard effect size | p | |
|---|---|---|---|---|---|
| TSQM, mean ± SD | |||||
| Effectiveness |
62 ± 10 |
82 ± 16 |
+20 ± 21 |
2.0 |
<0.0001 |
| Side effects |
85 ± 21 |
85 ± 18 |
0 ± 22 |
0 |
0.97 |
| Convenience |
44 ± 24 |
83 ± 17 |
+39 ± 26 |
1.6 |
<0.0001 |
| Global satisfaction |
61 ± 23 |
82 ± 18 |
+20 ± 24 |
0.9 |
<0.0001 |
| 6-minute walk distance, mean ± SD, m |
395 ± 79 |
414 ± 84 |
+16 ± 35 |
0.2 |
0.0005 |
| Medication administration time, mean ± SD, min./day | |||||
| Gather supplies |
21 ± 24 |
12 ± 11 |
−9 ± 26 |
0.4 |
0.01 |
| Prepare system |
11 ± 8 |
9 ± 9 |
−2 ± 12 |
0.3 |
0.16 |
| Inhalation |
66 ± 35 |
13 ± 7 |
−53 ± 37 |
1.5 |
<0.0001 |
| Clean |
21 ± 47 |
5 ± 4 |
−16 ± 46 |
0.3 |
0.01 |
| Total time |
119 ± 78 |
39 ± 25 |
−80 ± 81 |
1.0 |
<0.0001 |
| Adverse events, median (IQR) | |||||
| Severity-weighted adverse event score | - | 4.4 ± 2.8 | - | - | - |
IQR: interquartile range.
6-minute walk distance missing for 2 subjects.
Medication administration time missing data for 5 subjects.