Table 4.
Bioinformatic analysis to identify the existence of potential regulations in the C1R-mediated cluster through pathway enrichment analysis
| Pathway names | Enriched genes in pathway | P value | Adjust P value |
|---|---|---|---|
|
1. Pathway Commons database |
|||
| Inflammatory Response Pathway |
IL4R, THBS1 |
4.42e-05 |
0.0001 |
| Focal Adhesion |
ITGA5, SPP1, THBS1 |
2.93e-05 |
0.0001 |
| TGF Beta Signaling Pathway |
SPP1, THBS1 |
0.0001 |
0.0002 |
| Senescence and Autophagy |
CEBPB, THBS1 |
0.0002 |
0.0003 |
| Adipogenesis |
CEBPB, CEBPD |
0.0009 |
0.0009 |
| Initial triggering of complement |
C1R, CFB |
6.60e-05 |
0.0006 |
| Complement cascade |
C1R, CFB |
6.60e-05 |
0.0006 |
| Syndecan-4-mediated signaling events |
ITGA5, THBS1 |
0.0003 |
0.0019 |
| IL6-mediated signaling events |
CEBPB, CEBPD |
0.0003 |
0.0019 |
| Exocytosis of Alpha granule |
ITGA5, THBS1 |
0.0003 |
0.0019 |
| Platelet degranulation |
ITGA5, THBS1 |
0.0004 |
0.0024 |
| IL4-mediated signaling events |
CEBPB, IL4R |
0.0005 |
0.0026 |
| Response to elevated platelet cytosolic Ca++ |
ITGA5, THBS1 |
0.0005 |
0.0026 |
| Innate Immunity Signaling |
C1R, CFB |
0.0007 |
0.0030 |
| Platelet Activation |
ITGA5, THBS1 |
0.0008 |
0.0033 |
| Regulation of p38-alpha and p38-beta |
CEBPB, PTPN1 |
0.0028 |
0.0104 |
| Proteogylcan syndecan-mediated signaling events |
ITGA5, THBS1 |
0.0035 |
0.0124 |
| p38 MAPK signaling pathway |
CEBPB, PTPN1 |
0.0037 |
0.0125 |
| Plasma membrane estrogen receptor signaling |
CEBPB, PTPN1 |
0.0048 |
0.0150 |
| BMP receptor signaling |
CEBPB, PTPN1 |
0.0053 |
0.0159 |
| Regulation of nuclear SMAD2/3 signaling |
CEBPB, PTPN1 |
0.0101 |
0.0246 |
| TGF-beta receptor signaling |
CEBPB, PTPN1 |
0.0101 |
0.0246 |
| Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
CEBPB, PTPN1 |
0.0101 |
0.0246 |
| Glypican 1 network |
CEBPB, PTPN1 |
0.0224 |
0.0380 |
| Glypican pathway |
CEBPB, PTPN1 |
0.0258 |
0.0386 |
|
2. Wikipathways database |
|||
| Inflammatory Response Pathway |
IL4R, THBS1 |
4.42e-05 |
0.0001 |
| Focal Adhesion |
ITGA5, SPP1, THBS1 |
2.93e-05 |
0.0001 |
| TGF Beta Signaling Pathway |
SPP1, THBS1 |
0.0001 |
0.0002 |
| Senescence and Autophagy |
CEBPB, THBS1 |
0.0002 |
0.0003 |
| Adipogenesis |
CEBPB, CEBPD |
0.0009 |
0.0009 |
|
3. KEGG database |
|||
| ECM-receptor interaction |
ITGA5, SPP1, THBS1 |
2.75e-06 |
1.65e-05 |
| Focal adhesion |
ITGA5, SPP1, THBS1 |
3.76e-05 |
0.0001 |
| Cytokine-cytokine receptor interaction |
IL4R, CXCL2, IL10RB |
8.72e-05 |
0.0002 |
| Complement and coagulation cascades |
C1R, CFB |
0.0002 |
0.0003 |
| Hematopoietic cell lineage |
ITGA5, IL4R |
0.0004 |
0.0005 |
| Jak-STAT signaling pathway | IL4R, IL10RB | 0.0012 | 0.0012 |