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. Author manuscript; available in PMC: 2013 Mar 28.
Published in final edited form as: Liver Int. 2009 Apr 20;29(8):1262–1272. doi: 10.1111/j.1478-3231.2009.02036.x

Fig. 6.

Fig. 6

Differential induction of fibrosis markers in high-fat (HF) diet-fed C57BL6 and 129/SVJ mice. Expression of various fibrosis-related genes, including (A) transforming growth factor-β (TGF-, (B) α-smooth muscle actin (α-SMA), (C) fibronectin (FN), (D) tissue inhibitor of metalloproteinase (TIMP)-1 and (E) collagen 1α1, was evaluated by quantitative reverse transcriptase polymerase chain reaction analysis of liver RNA from BL6 and 129/SVJ mice fed either control diet (Ctr, n = 11/group) or HF diets (HF, n = 26/group) for 6 months. Liver sections were stained with picrosirius red, and collagen content was assessed by morphometry (F). Photomicrographs from a representative BL6 mouse (G) and a representative 129/SVJ mouse (H) after 6 months HF diet treatment. *P<0.05 vs respective Ctr; #P<0.05 vs BL6-HF group.