Table 1.
Characteristics of CRASP proteins
| CspA | CspZ | ErpA | ErpC | ErpP | |
|---|---|---|---|---|---|
| Synonyms and other | CRASP-1 | CRASP-2 | CRASP-5 | CRASP-4 | CRASP-3 |
| designations | BbCRASP-1 | BbCRASP-2 | BbCRASP-5 | BbCRASP-4 | BbCRASP-3 |
| BBA68 | BBH06 | ErpI | BBN38 | ||
| ZS7.A68 | ErpN | ||||
| FHBP | BBP38 | ||||
| BBL39 | |||||
| OspE | |||||
| Gene name | cspA | cspZ | erpA | erpC | erpP |
| Gene location in B. burgdorferi | lp54 | lp28-3 | cp32-1 | cp32-2 | cp32-9 |
| strain B31 | cp32-5 | ||||
| cp32-8 | |||||
| Gene family | PFam54 | None | PFam162 | PFam162 | PFam162 |
| Gene expression in unfed tick | No | No | No | No | No |
| Gene expression in feeding tick | Yes | No | Yes | Yes | Yes |
| Gene expression in skin at tick | Yes (high | Yes (low | Yes | Yes | Yes |
| feeding site | expression) | expression) | |||
| Gene expression in | No | Yes (high | Yes | Yes | Yes |
| mice/disseminated infection | expression) | ||||
| Susceptibility to proteolytic | Yes | No | Yes | Yes | Yes |
| degradation | |||||
| Confers serum resistance | Yes | Yes | No | No | No |
| Interaction of complement | CFH | CFH | CFHR1 | CFHR1 | CFHR1 |
| regulators with native CRASP | FHL1 | FHL1 | CFHR2 | CFHR2 | CFHR2 |
| CFHR5 | CFHR5 | ||||
| Interaction of complement | CFH | CFH | CFH | CFH | CFH |
| regulators with denaturated | FHL1 | FHL1 | CFHR1 | CFHR1 | CFHR1 |
| CRASP | CFHR2 | CFHR2 | CFHR2 | ||
| CFHR5 | CFHR5 | ||||
| Interaction with plasminogen | Yes | Yes | Yes | Yes | Yes |