Skip to main content
. Author manuscript; available in PMC: 2013 Mar 28.
Published in final edited form as: Cell. 2009 Feb 20;136(4):731–745. doi: 10.1016/j.cell.2009.01.042

Figure 3. Structures of the Bacterial Initiation Complex and CrPV IRES.

Figure 3

(A) Cryo-EM model of the 30S initiation complex from the bacterium Thermus thermophilus with small ribosomal subunit, mRNA, fMet-tRNAfMet, IF1, and GTP-bound IF2 (reprinted with permission from Macmillan Publishers Ltd: Simonetti et al., Nature 455, 416–420, 2008, copyright 2008).

(B) Structures of Dicistroviridae intergenic region IRESs. (Left) Secondary structure of Plautia stali intestine virus (PSIV) intergenic region, containing 3 pseudoknots (PKs), 2 conserved stem loops (SLs), and the non-AUG start codon as important components of the IRES. (Right) Crystal structures of domain 3 of cricket paralysis virus (CrPV) IRES (boxed) and the P-site tRNA-mRNA interaction in the bacterial 70S complex, with anticodon loop in red and mRNA codon in blue (reprinted from Kieft, 2008).