Table 2.

Change from baseline in global psychopathology, abnormal movements, functional status, global clinical status, and laboratory values

Variable	N	Baseline Mean (SD)	Endpoint Mean (SD)	Statistic
CGI-BP	53
Severity: mania		1.3 (0.6)	1.4 (0.7)	t = −0.59, df = 52, p = 0.56
Severity: depression		4.6 (0.8)	2.4 (1.2)	t = 11.31, df = 52, p < 0.01
Severity: overall		4.6 (0.8)	2.5 (1.2)	t = 10.09, df = 52, p < 0.01
AIMS	48	2.0 (3.7)	1.2 (2.7)	t = 1.81, df = 47, p = 0.08
Simpson Angus Scale	48	0.77 (1.61)	0.73 (1.51)	t = 0.26, df = 47, p = 0.80
Barnes Akathisia Scale	47	0.81 (2.28)	0.28 (0.97)	t = 2.16, df = 46, p = 0.04
SF-12 45
Mental score		29.5 (10.1)	43.5 (11.8)	t = −7.72, df = 44, p < 0.01
Physical score		42.1 (12.9)	41.0 (12.3)	t = 0.61, df = 44, p = 0.54
WHO-DAS II (subscales)	47
Getting around		5.1 (3.0)	4.9 (3.0)	t = 0.93, df = 46, p = 0.36
Self care		3.5 (2.0)	2.9 (1.8)	t = 2.93, df = 46, p < 0.01
Life activities		2.9 (1.2)	2.3 (1.4)	t = 2.94, df = 46, p < 0.01
Understand/communicate		4.7 (1.9)	3.4 (1.7)	t = 4.08, df = 46, p < 0.01
Participation in society		6.0 (2.0)	4.1 (2.0)	t = 6.03, df = 46, p < 0.01
Getting along with people		4.1 (2.1)	2.9 (1.7)	t = 3.89, df = 46, p < 0.01
Physical parameters
Body weight (lbs)	52	196.7 (40.7)	197.6 (40.3)	t = −0.92, df = 51, p = 0.36
Body weight (kg)		89.3 (18.5)	89.7 (18.1)
Serum glucose	42	107 (43.4)	101 (25.7)	t = 1.06, df = 41, p = 0.29
Total cholesterol	41	192 (55.6)	183 (46.0)	t = 1.77, df = 40, p = 0.08
Triglycerides	42	168 (108.7)	144 (91.4)	t = 1.75, df = 41, p = 0.09

CGI-BP = Clinical Global Impression–Bipolar version; AIMS = Abnormal Involuntary Movement Scale; SF-12 = Medical Outcomes Study Short Form General Health Survey; WHO-DAS II = WHO-Disability Assessment Schedule II.