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. 2013 Mar 19;7:149–159. doi: 10.2147/DDDT.S42390

Table 2.

The DNA damage repair and transcription genes differentially expressed in PC-2 cells induced by RPM

Genbank ID Gene description Ratio (Cy5/Cy3)
NM_016931 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) 0.16
NM-001923 Damage-specific DNA binding protein (DDB1) 0.20
NM_018682 Myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) (MLL5) 0.21
NM_013974 Dimethylarginine dimethylaminohydrolase 2 (DDAH2) 0.23
NM_001675 Activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4) 0.27
NM_003489 Nuclear receptor interacting protein 1 (NRIP1) 0.28
BC049823 Ribosomal protein L22-like 1 (RPL22) 0.30
NM_175623 RAB3A interacting protein (rabin3) (RAB3IP), transcript variant alpha 2 0.32
BC022217 Chromosome 6 open reading frame 85(C6ORF85) 0.33
NM-005431 X-ray repair complementing defective repair in Chinese hamster cells 2 (XRCC2) 0.33
NM_000689 Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1) 0.36
NM_002876 RAD51 homolog C (S. cerevisiae) (RAD51C), transcript variant 2 0.37
NM_001008712 RNA binding protein with multiple splicing (RBPMS), transcript variant 3 0.38
NM_139207 Nucleosome assembly protein 1-like 1 (NAP1L1) 0.39
NM_000075 Cyclin-dependent kinase 4 (CDK4) 0.40
NM_053277 Chloride intracellular channel 6 (CLIC6) 0.40
NM-021141 X-ray repair complementing defective repair in hamster cells 5 (XRCC5) 0.41
NM_001380 Dedicator of cytokinesis 1 (DOCK1) 0.42
NM_014515 CCR4-NOT transcription complex, subunit 2 (CNOT2) 0.42
NM_005655 Transforming growth factor-beta inducible early growth response (TGFBI EGR) 0.42
NM-003852 Transcriptional intermediary factor 1 (TIF 1) 0.43
NM_152721 Docking protein 6 (DOK6) 0.46
NM_139207 Nucleosome assembly protein 1-like 1 (NAP1L1) 0.46
NM_006312 Nuclear receptor corepressor 2 (NCOR2) 0.48
NM_000538 Regulatory factor X-associated protein (RFXAP) 0.49
NM_016545 Immediate early response 5 (IER5) 2.35
NM-002129 High-mobility group box 2 (HMGB2) 2.41
BC005107 Chromosome 21 open reading frame 105, mRNA (C21ORF10) 2.43
NM-006608 Putative homeodomain transcription factor 1 (PHTF 1) 2.57
NM_178820 F-box protein 27 (FBXO27) 2.61
NM_000927 ATP-binding cassette, subfamily B (MDR/TAP), member 1 (ABCB1) 2.73
NM_002592 Proliferating cell nuclear antigen (PCNA) 2.85
NM_001924 Growth arrest and DNA-damage-inducible, alpha (GADD45A) 2.91
NM_012153 Ets homologous factor (EHF) 3.13
NM_005845 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 (ABCC4) 3.24
NM_199242 Unc-13 homolog D (C. elegans) (UNC13D) 3.24
NM_172366 F-box protein 16 (FBXO16) 3.28
NM_000107 Damage-specific DNA binding protein 2 (DDB2) 3.35
NM_000392 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (ABCC2) 3.38
NM_002439 MutS homolog 3 (MSH3) 3.42
NM_020165 RAD18 homolog (S. cerevisiae) (RAD18) 3.45
NM_006332 Interferon, gamma-inducible protein 30 (IFI30) 3.57
NM_018965 Triggering receptor expressed on myeloid cells 2 (TREM2) 4.35
BC009507 Interferon, alpha-inducible protein (clone IFI-15K) 6.59

Notes: Total RNA from PC-2 cells treated with 10 nmol/L RPM for 48 hours was extracted for microarray analysis. Representative genes were significantly upregulated or downregulated by RPM in PC-2 cells.

Abbreviation: RPM, rapamycin.