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. Author manuscript; available in PMC: 2013 Mar 28.
Published in final edited form as: Pigment Cell Melanoma Res. 2009 May 28;22(4):400–419. doi: 10.1111/j.1755-148X.2009.00585.x

Figure 4. PTEN loss leads to preferential increase in Akt3 activity in melanomacytes and radial growth phase melananoma cells.

Figure 4

Normal human melanocytes and a cell line derived from a radial growth phase of melanoma (WM35) that contain low pAkt levels were transfected with siRNA targeting PTEN and/or one of the isoforms of Akt. A significant decrease in pAkt was noticed only when PTEN and Akt3 were targeted together but not with either PTEN and Akt1 or PTEN and Akt2, indicating that Akt3 is activated preferentially following PTEN loss (Stahl et al., 2004).