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Shown are the three classes of IL-2 receptors (high-affinity, intermediate affinity, and low affinity), with receptor composition, Kd’s, receptor composition, and associated JAK kinases. Also shown is trans-presentation of IL-2 by a DC that expresses IL-2Rα to a T cell that expresses IL-2Rβ and γc. On the right is the soluble IL-2 receptor (soluble IL-2Rα) with bound IL-2. As discussed in the text, IL-2 is produced primarily by activated CD4+ T cells.
