Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cytosolic receptors that sense viruses and induce inflammasome activation. NLRP3, AIM2, IFI16 sense viral infections and recruit ASC to form caspase-1-containing inflammasome complexes. The autoproteolytic processing of procaspase-1 results in the generation of active caspase-1, which then processes proIL-1β and proIL-18 to IL-1β and IL-18, respectively. The active caspase-1 also mediates an inflammatory form of cell death called pyroptosis.
