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. 2013 Mar 28;9(3):e1003236. doi: 10.1371/journal.ppat.1003236

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© 2013 Tyler et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Kaplan-Meier survival curve; B: Acute tubular necrosis score; C: Body weight at necropsy; D: Urine specific gravity; E: Hematoxylin and Eosin stained section of kidney from a mouse inoculated with EDL933. Many tubules are necrotic and contain cellular debris (arrows). A few glomeruli contain fibrin thrombi (arrowheads). F. Mouse infected with the EDL933cIind1 negative mutant. Tubules and glomeruli are normal. Bars = 50 microns. * Significantly different from mice infected with Ind- or Stx- mutants, p<0.001. Slides were scored blind without knowledge of their source. Animals were euthanized and tissues removed for examination; at 10 days post infection with EDL933 (day at which they became moribund) and at 21 days post infection with EDL933cIind1I (did not become moribund).