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. 2013 Mar 28;9(3):e1003004. doi: 10.1371/journal.pcbi.1003004

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© 2013 Mukhopadhyay et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) The concentration of total -chain phosphorylation as a function of the relative concentration of active kinase (E) to phosphatase (F). Results are shown for sequential phosphorylation (blue, green) and random phosphorylation (red, orange) in the absence (blue, red) and presence (green, orange) of ZAP-70. B) Hill numbers and C) for all four curves reveal that ZAP-70 binding dramatically increases both ultrasensitivity and potency when phosphorylation is sequential but not random.

Inline graphic — A) The concentration of total -chain phosphorylation as a function of the relative concentration of active kinase (E) to phosphatase (F). Results are shown for sequential phosphorylation (blue, green) and random phosphorylation (red, orange) in the absence (blue, red) and presence (green, orange) of ZAP-70. B) Hill numbers and C) for all four curves reveal that ZAP-70 binding dramatically increases both ultrasensitivity and potency when phosphorylation is sequential but not random.