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. 2012 Nov 21;6(4):704–717. doi: 10.1038/mi.2012.108

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Copyright © 2013 Society for Mucosal Immunology

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Interleukin-21 (IL-21) depletion has no effect on FoxP3, RORγt (related orphan receptor-γt), and T-bet expression by splenic CD4 T cells after priming with recombinant vaccinia virus. Mice were immunized as described in Figure 2. Fourteen days post priming, spleens were harvested. CD4 T cells were stained for (a) FoxP3, (b) RORγt, or (c) T-bet according to the manufacturer's instructions. The percentage of CD4 T cells expressing each transcription factor was determined by flow cytometry and is shown in each dotplot. Grouped data for (d) percentage and (e) total number are also shown. The graph is representative of two independent experiments of five mice per group. Con, control; Dep, depleted.