Figure 3. Combinatory effects with ZOL and CDDP in an orthotopic animal model.

MSTO-211H cells (1×10⁶) were inoculated into the pleural cavity of BALB/c nu/nu mice (n = 6) (day 1), and then ZOL (25 µg, day 3) was administrated into the pleural cavity and/or CDDP (100 µg, day 5) into the peritoneal cavity (CDDP). PBS was used as a control. Tumor weights were measured on day 24. The SE bars are also shown. * P<0.05, ** P<0.01.