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. 2013 Mar 28;8(3):e60003. doi: 10.1371/journal.pone.0060003

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© 2013 Higuma et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–C) Age at onset and (D–F) disease duration (time from disease onset to death or to when the condition was confirmed) were compared between patients with and without (A, D) PrP^Sc protein or (B, E) 14-3-3 protein. In addition, (C, F) the correlation between these clinical features and the concentration of tau protein in CSF was examined for patients with the P102L, P105L, V180I, E200K, or M232R mutation.